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某些双季铵盐对神经系统具有若干不同药理作用,例如阻滞神经节及神经肌间兴奋的传导以及抑制胆碱酯酶作用等,因而在医疗上获有应用,如有的神经节阻滞剂用作降低血压药物。Funke 等曾报导一系列带有苯氧基双季铵盐(Ⅳ,n=2-5)具有强烈抗箭毒作用,这些化合物是芳香胺衍生物。现在我们合成了一系列结构有关的脂肪胺衍生物(Ⅲ)。脂肪胺及芳香胺的碱性不同,表现的药理性质也可能因而各异。这里先报导这系列中的一个化合物(Ⅲ,n=2)的合成。
Some double quaternary ammonium on the nervous system has a number of different pharmacological effects, such as blocking the ganglia and nerve conduction between the excitability and the inhibition of cholinesterase and so on, which have been used in medicine, such as the resistance of some ganglia Anti-depressants used to lower blood pressure drugs. Funke et al. Have reported a series of strong anti-arcuate effects with phenoxyquaternium (IV, n = 2-5). These compounds are aromatic amine derivatives. Now we have synthesized a series of structurally related fatty amine derivatives (Ⅲ). The basicity of fatty amines and aromatic amines is different, the performance of the pharmacological properties may also be different. Here we first report the synthesis of one of the compounds in this series (III, n = 2).