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目的:观察莫沙必利联合常规治疗消化性溃疡的疗效。方法:选择临床确诊的消化性溃疡100例,随机分为观察组和对照组各50例。对照组采用常规治疗,观察组在对照组治疗基础上加用莫沙必利治疗;比较两组临床疗效、不良反应及溃疡愈合情况。结果:观察组显效26例(52.0%),有效23例(46.0%),无效1例(2.0%),总有效率98.0%;对照组显效18例(36.0%),有效25例(50.0%),无效7例(14.0%),总有效率86.0%;观察组总有效率显著高于对照组(P<0.05)。观察组治疗后溃疡指数、黏膜肌层缺损宽度、再生黏膜厚度及炎症细胞密度,均显著优于对照组治疗后(P<0.05)。观察组治疗期间出现腹泻4例、头晕1例、轻微腹痛1例,不良反应发生率为12.0%;对照组治疗期间出现轻微腹泻3例、头晕2例,不良反应发生率为10.0%;两组不良反应发生率比较,差异不显著(P>0.05)。结论:莫沙必利联合常规治疗消化性溃疡的疗效较好。
Objective: To observe the efficacy of mosapride combined with conventional treatment of peptic ulcer. Methods: 100 patients with clinically diagnosed peptic ulcer were randomly divided into observation group (50 cases) and control group (50 cases). The control group received routine treatment. The observation group was treated with mosapride on the basis of the control group. Clinical curative effect, side effects and ulcer healing were compared between the two groups. Results: The observation group was effective in 26 cases (52.0%), effective in 23 cases (46.0%), ineffective in 1 case (2.0%), the total effective rate was 98.0% ), 7 cases (14.0%) were ineffective and the total effective rate was 86.0%. The total effective rate in observation group was significantly higher than that in control group (P <0.05). After treatment, the ulcer index, mucosal muscle defect width, regenerative mucosa thickness and inflammatory cell density in the observation group were significantly better than those in the control group (P <0.05). In the observation group, 4 cases of diarrhea, 1 case of dizziness, 1 case of mild abdominal pain and 12.0% of adverse reactions occurred in the observation group. In the control group, there were 3 cases of mild diarrhea and 2 cases of dizziness. The incidence of adverse reactions was 10.0% The incidence of adverse reactions, the difference was not significant (P> 0.05). Conclusion: Mosapride combined with conventional treatment of peptic ulcer effect is good.