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目的探讨拉莫三嗪(LTG)与卡马西平(CBZ)联用时对儿童药物代谢及血药浓度的影响。方法对2~12岁的18例联用LTG和CBZ的癫痫患儿以及43例单用LTG或CBZ者血药浓度测定值进行比较。结果联用药组比单用药组LTG血药浓度明显降低(P<0.01),CBZ血药浓度差异无统计学意义(P>0.05)。结论患儿在联用LTG和CBZ后与单用时相比LTG血浓度降低,CBZ血浓度不变,联用时应适量增加LTG给药剂量。
Objective To investigate the effects of combination of lamotrigine (LTG) and carbamazepine (CBZ) on drug metabolism and plasma concentration in children. Methods 18 children aged 2 to 12 years with LTG and CBZ epilepsy in children and 43 patients with LTG or CBZ plasma concentrations were compared. Results The blood concentration of LTG in combination group was significantly lower than that of single group (P <0.01), while the concentration of CBZ in plasma was no significant difference (P> 0.05). Conclusion In children with LTG and CBZ combined with LTG blood concentration decreased compared with single use, CBZ blood concentration unchanged, combined with appropriate amount of LTG should be increased.