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白细胞介素－２（ｉｎｔｅｒｌｅｕｋｉｎ－２，ＩＬ－２）在Ｔ淋巴细胞及其它免疫细胞活化、分化和增殖等过程中起着非常重要的作用，我们通过观察肝硬化患者外周血淋巴细胞（ｐｅｒｉｐｈｅｒａｌｂｌｏｏｄｌｙｍ－ｐｈｏｃｙｔｅｓ，ＰＢＬ）ＩＬ－２ｍＲＮＡ的表达，以及ＩＬ－２分泌水平的改变，探讨肝硬化患者淋巴细胞ＩＬ－２分泌不足的机理。实验结果显示，肝硬化患者ＩＬ－２ｍＲＮＡ表达较正常对照明显减弱，表达细胞数未见明显变化；ＰＢＬ转化后ＩＬ－２ｍＲＮＡ表达增强，但肝硬化患者较对照仍有明显差异，ＩＬ－２分泌在肝硬化患者明显低于正常对照；淋巴细胞活化后，肝硬化患者与对照无明显差异。结果表明，许多有害因素通过降低外周血淋巴细胞ＩＬ－２ｍＲＮＡ的表达，影响ＩＬ－２产生、分泌，导致肝硬化患者免疫功能降低。
Interleukin-2 (IL-2) plays a very important role in the activation, differentiation and proliferation of T lymphocytes and other immune cells. By observing the peripheral blood lymphocytes in patients with cirrhosis, phocytes PBL) IL-2mRNA expression, as well as IL-2 secretion levels, to explore the mechanism of insufficient secretion of IL-2 in patients with liver cirrhosis. The results showed that the expression of IL-2mRNA in cirrhotic patients was significantly weaker than that in normal controls, and there was no significant change in the number of cells. The expression of IL-2mRNA increased after PBL conversion, but there was still significant difference between the patients with cirrhosis and control Patients with cirrhosis were significantly lower than the normal control; lymphocyte activation, cirrhosis patients and no significant difference. The results showed that many harmful factors could reduce the IL-2 production and secretion by reducing the expression of IL-2 mRNA in peripheral blood lymphocytes, resulting in decreased immune function in cirrhotic patients.