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目的探讨老年维持性血液透析(MHD)患者使用左卡尼汀对营养状态的影响。方法选取2015年7月至2016年6月在顺德区第二人民医院行规律血液透析治疗的老年MHD患者88例,根据是否使用左卡尼汀干预分为观察组(45例)与对照组(43例)。比较两组患者治疗前后白蛋白(ALB)、前白蛋白(PA)、C反应蛋白(CRP)、转铁蛋白(TF)、总胆固醇水平(TC)和营养状态,并记录治疗组治疗过程中的不良反应发生情况。结果治疗后,观察组患者体重明显高于对照组,差异有统计学意义(P<0.05);观察组患者治疗期间低血压、肌肉痉挛、食欲增加、呕吐、恶心发生率均显著低于对照组,差异均有统计学意义(均P<0.05);治疗后,观察组患者的ALB、PA、TRF以及SGA评分均明显高于对照组,CRP明显低于对照组,差异均有统计学意义(均P<0.05)。结论左卡尼汀能有效提高老年MHD患者的营养状况。
Objective To investigate the effects of levocarnitine on nutritional status in elderly patients with maintenance hemodialysis (MHD). Methods Eighty-eight elderly patients with MHD undergoing regular hemodialysis from July 2015 to June 2016 in Shunde Second People’s Hospital were divided into observation group (45 cases) and control group (n = 43 cases). The levels of albumin (ALB), prealbumin (PA), C reactive protein (CRP), transferrin (TF), total cholesterol (TC) and nutritional status of the two groups were compared before and after treatment. Adverse reactions occurred. Results After treatment, the body weight of the observation group was significantly higher than that of the control group (P <0.05). The incidences of hypotension, muscle spasm, increased appetite, vomiting and nausea in the observation group were significantly lower than those in the control group (All P <0.05). After treatment, the scores of ALB, PA, TRF and SGA in the observation group were significantly higher than those in the control group, and the CRP was significantly lower than that in the control group (all P <0.05) All P <0.05). Conclusion L-carnitine can effectively improve the nutritional status of elderly patients with MHD.