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目的了解浙江省绍兴地区女性宫颈人乳头瘤病毒(human papilloma virus,HPV)感染及亚型分布状况,为针对我国女性生殖器疣、宫颈癌防治,HPV疫苗的研制与推广提供参考。方法采用回顾性观察分析法,收集2008年1月至2012年10月在绍兴市妇幼保健院对健康体检女性进行宫颈HPV感染筛检者,统计分析其HPV感染及亚型分布情况。结果 5521名健康体检女性,HPV总感染754例,总感染率为13.7%(754/5521)。其中高危型感染占83.7%(631/754),低危型感染占14.3%(108/754);单一感染占85.1%(642/754),多重感染占14.9%(112/754);21个亚型中HPV-16感染位居首位,占22.5%(170/754),其次依次为HPV-52,HPV-58,HPVcp8304和HPV-33;各年龄段总HPV感染率差异无统计学意义(P<0.05)。结论绍兴地区普通女性HPV总感染率为13.7%,以高危型、单一感染为主,排名前10位亚型依次为16、52、58、cp8304、33、11、18、53、6、68。HPV亚型分布存在地区差异。
Objective To investigate the infection and subtype distribution of human papilloma virus (HPV) in women in Shaoxing, Zhejiang Province, and to provide reference for the development and promotion of female genital warts, cervical cancer prevention and treatment and HPV vaccine in China. Methods A retrospective analysis method was used to collect cervical HPV infection screening of healthy women in Shaoxing Maternal and Child Health Hospital from January 2008 to October 2012. The HPV infection and subtype distribution were statistically analyzed. Results A total of 5521 women were tested for health examination. The total number of HPV infection was 754, with a total infection rate of 13.7% (754/5521). Among them, high-risk infection accounted for 83.7% (631/754), low-risk infection accounted for 14.3% (108/754), single infection accounted for 85.1% (642/754), multiple infections accounted for 14.9% (112/754), 21 HPV-52, HPV-58, HPVcp8304 and HPV-33 were the most common subtypes in the subtype, accounting for 22.5% (170/754), followed by HPV-52, HPV588 and HPV-33. There was no significant difference in the total HPV infection rate P <0.05). Conclusion The total HPV infection rate of ordinary women in Shaoxing is 13.7%, mainly in high-risk and single-infection. The top 10 subtypes are 16,52,58, cp8304,33,11,18,53,6,68. There are regional differences in the distribution of HPV subtypes.