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目的 :评定硫酸吗啡控释片 (MST)直肠给药对中、重度癌性疼痛的镇痛疗效。方法 :采用自身对照法。 48例伴有中、重度癌性疼痛病人先口服MST6天 ,然后改为MST直肠给药 6天。结果 :MST直肠给药有效率和显著有效率 (明显缓解 +完全缓解 )分别为 95 83%与 81 2 5 %。治疗后疼痛明显减轻 ,生活质量明显提高 ,直肠给药与口服给药相比疗效无显著差异 (P >0 0 5 )。副作用与口服给药相同 ,主要为嗜睡、恶心、呕吐、便秘。结论 :MST直肠给药具有良好镇痛效果 ,尤其适合于不能口服给药的晚期癌症患者。
Objective: To evaluate the analgesic effect of rectal administration of morphine sulfate controlled release tablets (MST) on moderate and severe cancerous pain. Methods: using self-control method. Forty-eight patients with moderate-to-severe cancerous pain were treated with oral MST for 6 days and then with MST for 6 days. Results: The efficacies and significant efficacies of rectal administration of MST (significant relief + complete remission) were 95 83% and 81 2 5% respectively. After treatment, the pain was relieved and the quality of life was significantly improved. There was no significant difference between rectal administration and oral administration (P> 0.05). Side effects and oral administration of the same, mainly drowsiness, nausea, vomiting, constipation. Conclusion: MST rectal administration has good analgesic effect, especially for advanced cancer patients who can not be orally administered.