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几乎经历了二个世纪一直认为心血管疾病(CVD)是服用含雌孕激素口服避孕药(COCs)最严重的副反应。经流行病学和其它研究得到大量证据提示脂代谢紊乱和CVD的发生有关系,通过此机理,COC可影响CVD的发生,本文综述CVD与COC应用和脂代谢间的联系。脂类与CVD:低密度脂蛋白(LDL)携带60～70%的血清胆固醇,而高胆固醇血症一般反映LDL增加,因此低密度脂蛋白-胆固醇(LDL-C)水
Almost two centuries have been the belief that cardiovascular disease (CVD) is the most serious side effect of taking oral contraceptives (estrogen-progestogen-containing contraceptives). Evidence from epidemiology and other studies has yielded evidence that dyslipidemia is associated with the development of CVD through which COC can influence the incidence of CVD. This review summarizes the link between CVD and COC use and lipid metabolism. Lipids and CVD: Low-density lipoproteins (LDLs) carry 60-70% serum cholesterol, whereas hypercholesterolemia generally reflects an increase in LDL, so low-density lipoprotein-cholesterol (LDL-C)