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目的探讨不同空腹血糖水平(FBG)对中老年人踝臂指数(ABI)的影响。方法在2006年~2007年参加健康体检的101510例开滦集团职工中随机分层抽取5852例作为研究对象,进行统一问卷调查及血液生化检查,符合入选标准的为5440例。于2010年~2011年进行第三次健康体检并测量ABI,最终纳入统计分析的有效数据为5189例。根据美国糖尿病协会指南,按FBG将研究人群分成三组:理想血糖组(FBG<5.6 mmol/L)、空腹血糖受损(IFG)组(5.6 mmol/L≤FBG<7.0 mmol/L)、糖尿病组(FBG≥7.0 mmol/L或糖尿病患者)。对影响ABI的相关危险因素进行多因素Logistic回归分析。结果理想血糖组、IFG组、糖尿病组ABI分别为1.10±0.09、1.09±0.11、1.08±0.13(P<0.05),ABI≤0.9的检出率分别为2.97%、4.74%、8.81%(P<0.05)。多因素Logistic回归分析显示,糖尿病为ABI≤0.9的危险因素,其OR值为1.97(95%CI为1.32~2.96);在女性人群中,IFG、糖尿病均为ABI≤0.9的危险因素,其OR值分别为2.26(95%CI为1.25~4.07)、2.37(95%CI为1.06~5.26)。结论空腹血糖是影响中老年人群ABI的独立危险因素,在女性人群中更加显著。
Objective To investigate the effect of different fasting blood glucose levels (FBG) on the ankle-brachial index (ABI) of middle-aged and elderly people. Methods A total of 5852 cases of Kailuan Group from 101510 Kailuan Group, who took part in the physical examination from 2006 to 2007, were randomized to take part in the questionnaire survey and blood biochemical examination. 5440 cases met the inclusion criteria. A third physical examination and measurement of ABI were performed from 2010 to 2011, and finally the data for inclusion in the statistical analysis were 5,189. According to the guidelines of the American Diabetes Association, the study population was divided into three groups according to the FBG: ideal glucose group (FBG <5.6 mmol / L), impaired fasting glucose (IFG) group (5.6 mmol / L and FBG <7.0 mmol / L) Group (FBG≥7.0 mmol / L or diabetic patients). Multivariate Logistic regression analysis was performed on the relevant risk factors affecting ABI. Results The ABI of ideal blood glucose group, IFG group and diabetes group were 1.10 ± 0.09, 1.09 ± 0.11 and 1.08 ± 0.13 respectively (P <0.05), and the detection rates of ABI≤0.9 were 2.97%, 4.74% and 8.81% respectively (P < 0.05). Multivariate Logistic regression analysis showed that diabetes was the risk factor with ABI≤0.9, and the odds ratio (OR) was 1.97 (95% CI: 1.32-2.96). In the female population, IFG and diabetes were all risk factors with ABI≤0.9. OR The values were 2.26 (95% CI 1.25 to 4.07) and 2.37 (95% CI 1.06 to 5.26). Conclusion Fasting plasma glucose is an independent risk factor for ABI in middle-aged and elderly people, which is more significant in female population.