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目的：探讨B超定位联合X线引导经皮经肝穿刺碎石取石术对肝内胆管结石的临床效果。 方法：选取2015年6月—2016年2月在收治的肝内胆管结石患者，并随机分为对照组和观察组，每组30例，观察组行B超定位联合X线引导经皮经肝穿刺碎石取石术，对照组行单纯X线引导经皮经肝穿刺碎石取石术，比较两组患者相关临床指标以及术后6个月生活质量情况。 结果：与对照组比较，观察组住院时间和胃肠道蠕动恢复时间均无统计学差异（均P>0.05），但手术时间明显缩短（69.46 minvs.158.67 min），出血量明显减少（35.15 mLvs.102.76 mL），手术成功例数增多（30例vs.25例），结石残留和近期复发例数明显减少（0例vs.6例；0例vs.4例），术后急性胰腺炎、急性胆管炎、胆汁漏和出血发生率明显降低，术后6个月SF-36量表各项指标评分均明显增高（均P0.05), but operative time (69.46 minvs. 158.67 min), intraoperative blood loss (35.15 mLvs. 102.76 mL) were signiifcantly reduced, the number of cases with surgical success (30vs. 25) was signiifcantly increased, the number of cases with residual stones (0vs. 6) and early recurrence (0vs. 4) were significantly decreased, the incidence of postoperative acute pancreatitis, acute cholangitis, bile leakage and hemorrhage were all signiifcantly decreased, and the scores for all parameters of the SF-36 at 6 months atfer operation were all signiifcantly elevated (allP<0.05). Conclusion: Percutaneous transhepatic stone disintegration and extraction under B ultrasound positioning and X-ray guidance is a safe, effective and convenient method of treatment for hepatolithiasis. It also has advantages of accurate location, high stone clearance rate, short operative time and fewer complications.