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目的:探讨当归四逆汤防治化疗相关性手足综合征的临床疗效。方法:选择我院2014年10月至2016年6月期间在本院化疗治疗的恶性肿瘤患者作为受试者,随机分为对照组(37例)和观察组(37例)。两组患者均采用卡培他滨单药化疗,化疗期间:对照组采用维生素B6治疗,观察组采用当归四逆汤治疗,观察两组患者2个化疗周期结束后手足综合征发病率,并统计手足综合征分级情况。结果:观察组化疗相关性手足综合征分级Ⅰ度(8.11%)、Ⅱ度(5.41%)、Ⅲ度(2.70%)发生率均显著低于对照组(P<0.05)。观察组化疗相关性手足综合征总发生率(13.52%)显著低于对照组(59.46%),组间差异(P<0.05)。结论:卡培他滨化疗中采用当归四逆汤治疗,可有效降低化疗相关性手足综合征发病率及严重程度,有助于改善患者生活质量,提高预后效果。
Objective: To investigate the clinical effect of Danggui Sini Decoction in preventing and treating chemotherapy-related hand-foot syndrome. Methods: Patients with malignant tumor treated with chemotherapy in our hospital from October 2014 to June 2016 were randomly divided into control group (37 cases) and observation group (37 cases). Two groups of patients were treated with capecitabine monotherapy, during chemotherapy: the control group with vitamin B6 treatment, the observation group with Angelica Sini Decoction treatment of two groups of patients after two cycles of chemotherapy to observe the incidence of hand-foot syndrome and statistics Hand-foot syndrome grading. Results: The grade Ⅰ (8.11%), grade Ⅱ (5.41%) and grade Ⅲ (2.70%) were all significantly lower in the observation group than those in the control group (P <0.05). The total incidence of chemotherapy-related hand-foot syndrome (13.52%) in the observation group was significantly lower than that in the control group (59.46%) (P <0.05). Conclusion: Camptothecin chemotherapy using Angelica Sini decoction can effectively reduce the incidence of chemotherapy-related hand-foot syndrome and severity, help to improve the quality of life of patients and improve the prognosis.