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目的观察新诊断T2DM患者短期胰岛素泵强化降糖治疗后影响血糖长期控制的因素。方法选取新诊断T2DM患者32例,胰岛素泵治疗2周,测定治疗前后OGTT 0.5、1、2hPG及Ins,计算胰岛β细胞功能指数(HOMA-β)、胰岛素抵抗指数(HOMA-IR)和第一时相胰岛素分泌(ΔI30/ΔG30)。观察3年后血糖控制情况,分析影响因素。结果胰岛素泵强化治疗后,FPG、0.5hPG、2hPG、HOMA-IR均较治疗前下降,HOMA-β和ΔI30/ΔG30升高(P<0.01)。3年后血糖控制率为28.1%(9/32)。Logistic回归分析显示,强化治疗后有氧运动是血糖长期控制的重要因素(OR=24,P<0.05)。结论新诊断T2DM患者短期胰岛素泵强化治疗可长期控制血糖,有氧运动是血糖长期控制的重要因素。
Objective To observe the factors influencing the long-term control of blood glucose after short-term insulin pump intensive hypoglycemic treatment in newly diagnosed T2DM patients. Methods Thirty-two newly diagnosed T2DM patients were treated with insulin pump for 2 weeks. The levels of OGTT 0.5, 1, 2 h PG and Ins were measured before and after treatment. HOMA-β, HOMA-IR, Phase insulin secretion (ΔI30 / ΔG30). Observed 3 years after the control of blood glucose, analysis of influencing factors. Results After intensive insulin treatment, the levels of FPG, 0.5hPG, 2hPG and HOMA-IR decreased compared with before treatment, and HOMA-β and ΔI30 / ΔG30 increased (P <0.01). Three years later, the rate of glycemic control was 28.1% (9/32). Logistic regression analysis showed that aerobic exercise after intensive treatment was an important factor in the long-term control of blood glucose (OR = 24, P <0.05). Conclusion Newly diagnosed T2DM patients with short-term intensive insulin therapy can control long-term blood glucose, aerobic exercise is an important factor in the long-term control of blood glucose.