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目的:探讨MEBO半暴露与INN促痂两种治疗方案对颜面部合并耳廓部位深度烧伤患者愈合效果、疼痛程度及炎性细胞因子的影响。方法:研究对象选取丽水市人民医院2014年3月-2016年3月收治颜面部合并耳廓部位深度烧伤患者共100例,以随机抽签法分为对照组(50例)和观察组(50例),分别采用INN促痂和MEBO半暴露疗法治疗;比较两组患者创面愈合效果,创面愈合时间,创面病原菌转阴换药次数,治疗前后VAS评分,TNF-α,IL-6及IL-8水平等。结果:观察组患者创面愈合效果显著优于对照组(P<0.05);观察组患者创面愈合时间和创面病原菌转阴换药次数均显著优于对照组(P<0.05);两组患者治疗后7d、14d及28dVAS评分均显著低于治疗前(P<0.05);观察组患者治疗后7d、14d及28dVAS评分均显著低于对照组(P<0.05);两组患者治疗后炎症细胞因子水平均显著高于治疗前(P<0.05);观察组患者治疗后炎症细胞因子水平均显著低于对照组(P<0.05)。结论:MEBO半暴露疗法治疗颜面部合并耳廓部位深度烧伤可有效促进创面愈合,减轻疼痛程度,并有助于下调炎性细胞因子水平,价值优于INN促痂疗法。
Objective: To investigate the effects of MEBO semi-exposure and INN promoting scab on healing effect, pain degree and inflammatory cytokines in patients with facial burns complicated with deep burns in the auricle. Methods: The subjects selected Lishui People’s Hospital from March 2014 to March 2016 were treated 100 patients with facial burns and auricle deep burn patients were randomly divided into control group (50 cases) and observation group (50 cases ), Respectively, with INN scab and MEBO semi-exposure therapy treatment; wound healing, wound healing time, wound dressing number of wound dressing, VAS score, TNF-α, IL-6 and IL-8 Level and so on. Results: The wound healing in the observation group was significantly better than that in the control group (P <0.05). The wound healing time and the number of wound dressing wound dressing in the observation group were significantly better than those in the control group (P <0.05) The VAS scores at 7d, 14d and 28d after treatment were significantly lower than those before treatment (P <0.05). The VAS scores at 7d, 14d and 28d after treatment in observation group were significantly lower than those in control group (P <0.05). The levels of inflammatory cytokines (P <0.05). The levels of inflammatory cytokines in the observation group were significantly lower than those in the control group (P <0.05). CONCLUSION: MEBO semi-exposure therapy can effectively promote wound healing, relieve pain and reduce the level of inflammatory cytokines, which is better than INN.