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孕酮刺激下丘脑释放促性腺激素释放激素(GnRH)的分子机制不同于经典的甾体激素两步作用原理,可能通过其它的细胞机制发挥作用。为了探讨孕酮作用于下丘脑细胞可能存在的细胞膜机制,作者将孕酮连接在牛血清白蛋白(BSA)分子上,观察它们在用雌激素维持的去卵巢未成年大鼠的离体视前区-下丘脑前区-下丘脑内侧基底区(POA-AHA-MBA)低冷灌流系统中对 GnRH 释放的影响,结果表明,孕酮-3-羧甲基肟 BSA(P-3-BSA)可使 POA-AHA-MBA 释放 GnRH 逐渐增加,4h 后达到高峰;而孕酮-11α-半琥珀酰-BSA(P-11-BSA)和11-去氧可
Progesterone stimulates the hypothalamic release of gonadotropin-releasing hormone (GnRH) molecular mechanism is different from the classic two-step steroid hormone principle, may play a role through other cellular mechanisms. In order to explore the possible mechanism of cell membrane in the hypothalamic cells by progesterone, we linked progesterone to bovine serum albumin (BSA) molecules and observed their preexposure in ovariectomized young rats maintained by estrogen (P-3-BSA) on the release of GnRH in the hypothalamic-anterior hypothalamic-hypothalamic medial basal area (POA-AHA- The release of GnRH from POA-AHA-MBA gradually increased and peaked after 4h, whereas progesterone-11α-hemosuccinyl-BSA (P-11-BSA) and 11-deoxy