The Proteasomal Inhibitor MG132 Potentiates Apoptosis of Triptolide-Treated K562 Cells by Regulating

• 作 者: Weihua Chen Wanming Da Chunji
• 机 构: DepartmentofHematology
• 出 处: 中国肿瘤临床：英文版
• 发表日期: 2008年5期
• 关键词: MG132 中国药草 抗癌机制 白血病 MG132 triptolide TNF-α NF-κB/p65 cell line K562.
• 基金项目: This work was supported by a grant from the National Natural Science Foundation of China （N0.30570776）.We thank Dr. Lishen Wang of the Institute of Radiation Medicine, Academy of Military Medical Scie

OBJECTIVE To explore the anticancer mechanism of triptolide in human leukemia K562 cells,and to further determine whether the proteasomal inhibitor,MG132,can potentiate apoptosis in triptolide-treated K562 cells.METHODS Apoptosis was assessed via annexin