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报道1例接受酰胺咪嗪(CBZ)治疗而发生急性肾衰(ARF)者。患者男,38岁。应用CBZ400mg,日3次治疗癫痫4年,因焦虑和一过性意识丧失发作被送入精神病科,无肾脏病史。入院时,血清肌酐高达257umol/L,血钠降至129mmol/L。尿路造影未发现尿道结石。肾脏超声正常。入院第2天患者出现少尿,血肌酐811umol/L,血钾5.7mmol/L。胸片示双侧胸水。镜下血尿,尿蛋白200mg/L,血沉25mm。血清C反应蛋白和血清IgE升高。服用最后一次CBZ后12小时其血清CBZ浓度为52umol/L(治疗浓度为20～40umol/L)。予以纠正酸中毒和降低血钾治疗。并将CBZ改为苯妥英钠。2天后,尿量增多,血清肌酐下降并趋于正常。3周
One case of acute renal failure (ARF) treated with amidotriosine (CBZ) was reported. Male patient, 38 years old. Application of CBZ400mg, 3 times a day treatment of epilepsy 4 years, due to anxiety and transient loss of consciousness was sent to the Department of Psychiatry, no history of kidney disease. Admission, serum creatinine as high as 257umol / L, serum sodium decreased to 129mmol / L. Urethral calculi were not found in urography. Kidney ultrasound is normal. On the second day of hospitalization, patients presented with oliguria, serum creatinine 811umol / L and potassium potassium 5.7mmol / L. Chest radiograph showed bilateral pleural fluid. Microscopic hematuria, urinary protein 200mg / L, ESR 25mm. Serum C-reactive protein and serum IgE increased. After taking the last CBZ 12 hours serum CBZ concentration of 52umol / L (treatment concentration of 20 ~ 40umol / L). To correct acidosis and lower serum potassium treatment. CBZ and changed to phenytoin sodium. After 2 days, urine output increased, serum creatinine decreased and tended to be normal. 3 weeks