论文部分内容阅读
目的研究Caveolin-1在下咽鳞癌组织中的表达情况,探讨其在下咽鳞癌发生发展中的作用机制。方法采用免疫组化法检测Caveolin-1在69例下咽鳞癌及10例癌旁正常组织中的表达,统计分析两者之间的相关性。结果 Caveolin-1在下咽癌组织中的阳性率为34.78%,在对照组中Caveolin-1存在个别表达或无阳性表达,两者表达差异有统计学意义(P<0.05);Caveolin-1的表达程度与病理类型、转移相关,而与下咽鳞癌患者性别、临床分期和原发部位之间差异无统计学意义(P>0.05)。结论下咽鳞癌中Caveolin-1的表达明显增高并与肿瘤的转移行为有关,有可能作为下咽鳞癌预后不良的病理标志之一。
Objective To study the expression of Caveolin-1 in squamous cell carcinoma of the hypopharyngeal squamous cell carcinoma and to explore its mechanism in the pathogenesis of hypopharyngeal squamous cell carcinoma. Methods The expression of Caveolin-1 in 69 cases of hypopharyngeal squamous cell carcinoma and 10 cases of adjacent normal tissues was detected by immunohistochemistry. The correlation between them was statistically analyzed. Results The positive rate of Caveolin-1 in hypopharyngeal carcinoma was 34.78%. There was either no or no expression of Caveolin-1 in the control group (P <0.05). The expression of Caveolin-1 There was no significant difference in gender, clinical stage and primary site between squamous cell carcinoma and squamous cell carcinoma (P> 0.05). Conclusions The expression of Caveolin-1 in hypopharyngeal squamous cell carcinoma is significantly higher than that in the metastatic tumor, which may be one of the pathological markers of poor prognosis of the squamous cell carcinoma of the.