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目的 探讨辅用舒芬太尼对患者神经阻滞和循环呼吸的影响.方法 行坐骨神经-股神经阻滞的患者60例随机均分为三组:A组和B组分别予神经阻滞前10 min静脉注射舒芬太尼0.25和0.35 μg/kg,C组给予等容量生理盐水作为对照.监测入手术室后(T1)、神经阻滞穿刺前(T2)、穿刺中(T3)、外科切皮时(T4)、手术结束时(T5)的MAP、HR、RR、SpO2和VAS评分,记录感觉和运动神经阻滞时间,观察不良反应.结果 与T1时比较,C组T3时VAS评分上升(P＜0.05).与C组比较,A组T2、T3时VAS评分下降(P＜0.05).与A组比较,B组T3～T5时MAP和HR下降(P＜0.05),两组VAS评分差异无统计学意义(P＞0.05).与C组比较,A、B组感觉和运动阻滞时间延长(P＜o.05).B组有3例患者出现咳嗽、胸壁肌肉僵直,1例患者SpO2下降,面罩辅助呼吸后恢复正常.结论 舒芬太尼0.25μg/kg静脉注射能有效减轻神经阻滞穿刺疼痛,延长感觉和运动神经阻滞时间.“,”Objective To study the effects of auxiliary sulfentanil on nerve block and circulation and respiration functions.Methods Sixty patients undergoing selective surgery under sciatic-femoral nerve block were randomly and equally divided into 3 groups of A(intravenous injection of sufentanil 0.25 μg/kg at 10 minutes before nerve block),B(intravenous injection of sufentanil 0.35 μg/kg at 10 minutes before nerve block) and C(intravenous injection of same volume of normal saline as the control).MAP,HR,RR,SpO2 and VAS pain score were detected after entering the operation room (T1),before neural block(T2),at the times of puncture for neural block (T3) and skin incision (T4) and at the end of surgery (T5).The times of sensory and motor block were recorded.The adverse effects were observed.Results Compared with T1,VAS pain score was increased at T3 in group C (P＜0.05).Compared with group C,VAS pain scores at T2 and T3 were decreased in group A (P＜0.05).Compared with group A,MAP and HR were decreased at T3-T5 in group B(P＜0.05).There was no significant difference in VAS pain score between group A and B(P＞0.05).Compared with group C,the times of sensory and motor block were longer in groups of A and B(P＜0.05).Cough and stiffness of chest wall occurred in 3 cases in group B.One case of group B had a decline of SpO2,which was returned to normal after mask-assisted breathing.Conclusion Intravenous injection of sufentanil 0.25 μg/kg is able to attenuate puncture-induced pain and prolong the time of nerve block.