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目的探讨钆喷酸葡胺(Gd-DTPA)与碘海醇混合液作为放疗计划CT、MR图像配准体外标志的可行性。方法取Gd-DTPA加纯净水配制成不同浓度的稀释液,行T1WI、T2WI和FLAIR成像;选择在T1WI上信号强度最高者与碘海醇按不同比例配成混合液,再行MR、CT;测量不同比例混合液在MR各成像序列的信号强度及CT值。将达到标准的混合液密封于细塑料管中,作体模检测和临床应用。结果浓度为1.61 mg/ml Gd-DTPA稀释液在T1WI上信号强度最高;该稀释液与碘海醇按6∶1混合可达到体外标志设计标准;经临床应用,配准平均误差为(1.35±0.22)mm。结论将恰当比例的Gd-DTPA稀释液与碘海醇混合密封于细塑料管中,固定在定位热塑面罩的模拟校准线上,可作为放疗计划CT、MR图像配准的体外标志。
Objective To investigate the feasibility of using Gd-DTPA and iohexol as the in vitro markers for radiotherapy planning of CT and MR images. Methods TdI, T2WI and FLAIR imaging were performed by using Gd-DTPA and pure water. The T1WI and Iohexol were mixed at different ratios to make MR and CT. The signal intensities and CT values of the MR images at different ratios were measured. Will reach the standard mixture sealed in thin plastic tube for phantom testing and clinical applications. Results The concentration of Gd-DTPA was the highest on T1WI at a concentration of 1.61 mg / ml. The dilution was mixed with iohexol at a ratio of 6: 1 and reached the standard of in vitro design. The average error of registration was (1.35 ± 0.22) mm. Conclusion The appropriate proportion of Gd-DTPA diluent and iohexol were mixed and sealed in thin plastic tube and fixed on the simulated calibration line of positioning thermoplastic mask, which could be used as an in vitro marker for radiotherapy planning CT and MR image registration.