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目的:通过检测葡萄糖转运蛋白-1(GLUT-1)和血管内皮生成因子(VEGF)在子宫内膜病变中的表达,探讨其与子宫内膜样腺癌发生发展的关系。方法:应用免疫组化(PV9000二步法)检测36例子宫内膜样腺癌、18例子宫内膜不典型增生、12例复杂性增生和15例单纯性增生组织中GLUT-1和VEGF的表达。结果:GLUT-1和VEGF在子宫内膜样腺癌组织中的表达分别为83.3%和75.0%,与单纯性增生、复杂性增生及不典型增生组织相比较,差异均有统计学意义,P<0.05。子宫内膜病变组织中GLUT-1与VEGF表达水平间存在正相关关系,r=0.65,P<0.01。结论:GLUT-1和VEGF在子宫内膜病变由良性到恶性转变过程中起重要作用。VEGF通过上调GLUT-1的表达,促进子宫内膜样腺癌的发生发展,具有临床应用价值。
OBJECTIVE: To investigate the relationship between the expression of glucose transporter 1 (GLUT-1) and vascular endothelial growth factor (VEGF) in endometrial lesions and the development of endometrial adenocarcinoma. Methods: The expressions of GLUT-1 and VEGF in 36 cases of endometrial adenocarcinoma, 18 cases of endometrial dysplasia, 12 cases of complicated hyperplasia and 15 cases of simple hyperplastic tissues were detected by immunohistochemistry (PV9000 two-step method) expression. Results: The expressions of GLUT-1 and VEGF in endometrioid adenocarcinoma were 83.3% and 75.0%, respectively, which were significantly different from those in simple hyperplasia, hyperplasia and dysplasia <0.05. There was a positive correlation between the expression of GLUT-1 and VEGF in endometrial lesions, r = 0.65, P <0.01. Conclusion: GLUT-1 and VEGF play an important role in the process of benign to malignant transformation of endometrial lesions. VEGF has clinical value by up-regulating GLUT-1 expression and promoting the development of endometrial adenocarcinoma.