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为了解生命泉流浸膏(FESOL)抗单纯疱疹病毒Ⅱ型(HSV-2)的效果,以无环鸟苷(ACV)作对照药,采用MTT法和细胞病变(CPE)抑制法进行体外实验观察。结果:MTT法测得FESOL的TC50为1.39mg/ml,IC50为0.041mg/ml,治疗指数(TI)为33.9;以CPE抑制法测得FESOL的TC50为1.61mg/ml,IC50为0.055mg/ml,TI为29.27。与ACV相比,FESOL在体外有明显的抑制HSV-2的作用。
To understand the effect of FESOL on anti-herpes simplex virus type 2 (HSV-2), acyclovir (ACV) was used as a control drug and MTT assay and cytopathic effect (CPE) inhibition method were used to observe in vitro. . Results: The TC50 of FESOL measured by MTT assay was 1.39 mg/ml, IC50 was 0.041 mg/ml, and the therapeutic index (TI) was 33.9. The TC50 of FESOL measured by CPE inhibition method was 1.61 mg/ml. The IC50 was 0.055 mg/ml and the TI was 29.27. Compared with ACV, FESOL significantly inhibited HSV-2 in vitro.