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利用大心肌缺血、再灌注模型，观察了纳络酮对缺血再藻注心肌脂质过氧化物（ＬＰＯ）、超氧化物歧化酶（ＳＯＤ）和钙含量的影响。结果表明：缺血、再灌注心肌ＬＰＯ和钙含量明显增加（Ｐ＜０．０５，Ｐ＜０．０１），再灌注心肌ＬＰＯ含量和钙含量明显高于缺血心肌（Ｐ＜０．０５，Ｐ＜０．０１），而缺血、再灌注心肌ＳＯＤ明显降低（Ｐ＜０．０１）；纳络用明显降低缺血、再灌注心肌ＬＰＯ和钙含量（Ｐ＜０．０５，Ｐ＜００１），但对ＳＯＤ的影响不明显（Ｐ＞０．０５）。提示：纳络酮抑制心肌缺血、再灌注时的脂质过氧化物反应，部份阻止细胞外钙跨膜内流，对心肌只响保护作用。
The effects of naloxone on lipid peroxidation (LPO), superoxide dismutase (SOD) and calcium in myocardium of myocardial ischemia and reperfusion were observed by using model of myocardial ischemia and reperfusion. The results showed that the content of LPO and calcium in ischemia / reperfusion myocardium increased significantly (P <0.05, P <0.01), and the content of LPO and calcium in reperfusion myocardium was significantly higher than that in ischemic myocardium (P <0.05, (P <0.01), while the level of myocardial SOD was significantly decreased after ischemia and reperfusion (P <0.01). Naloxone significantly reduced the levels of LPO and Ca (P <0.05, P <0.001 ), But the effect on SOD was not obvious (P> 0.05). Tip: Naloxone inhibits myocardial ischemia, reperfusion lipid peroxidation, in part, prevent extracellular calcium transmembrane inflow, the heart only protects the role.