Enhancement of human ACAT1 gene expression to promote the macrophagederived foam cell formation by d

• 作 者: LiYANG JinBoYANG JiaCHEN Guang
• 机 构: StateKeyLaboratoryofMolecularBiology,DepartmentofBiochemistry,USA.
• 出 处: 细胞研究：英文版
• 发表日期: 2004年4期
• 关键词: 巨噬细胞 地塞米松 泡沫细胞 人类 基因 表达 ACAT 胆固醇酯 ACAT dexamethasone macrophage cholesteryl e
• 基金项目: 国家重点基础研究发展计划(973计划)，National Scienses Foudation Center，Technology Committee (SSTC)，中国科学院资助项目

In macrophages, the accumulation of cholesteryl esters synthesized by the activated acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT1) results in the foam cell formation, a hallmark of early atherosclerotic lesions. In this study,with the treatment of