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目的:观察固肾安胎方联合常规西药治疗肾脾两虚型复发性流产临床观察及相关免疫性。方法:采用回顾性分析随机选取2013年2月~2015年12月本院收治复发性流产(RSA)患者再次妊娠者60例,根据随机分组法分为两组,A组为研究组,采用固肾安胎方联合常规西药治疗方案;B组为参照组,采用常规西药治疗方案。结果:A、B两组患者自然流产次数对比,差异无意义(P=0.874)。A、B两组患者初诊时孕周对比,差异无意义(P=0.516)。A、B两组患者初诊时中医症状积分分别为(1.35±4.98)和(11.86±3.72),且A、B两组患者初诊时病情分级对比,差异无意义(P=0.264)。A、B两组患者治疗前血清(B-HCG)和孕酮水平的对比,差异无意义(P=0.617)。A组有1例患者胞胎失败,29例治愈,总有效率为96.7%。B组10例治疗无效,20例治愈,总有效率为66.7%。A、B两组患者治疗后妊娠结局的对比,差异有意义(P=0.026)。A组治愈8例,显效12例,有效7例,无效3例,总有效率为90.0%。B组治愈4例,显效6例,有效10例,无效10例,总有效率为66.7%。A、B两组治疗后中医症状改善情况对比,差异有意义(P=0.042)。A、B两组患者流产次数与好娘结局关系的对比,经过Fisher确切概率法分析,差异有意义(P=0.032)。A、B两组患者治疗后血清对比,差异无意义(P>0.05)。A、B两组患者治疗后的6和8周末孕酮对比,差异有意义(P<0.05);A、B两组患者治疗后的10周末孕酮对比,差异无意义(P>0.05)。结论:固肾安胎方联合常规西药治疗肾脾两虚型复发性流产效果显著,值得推广。
Objective: To observe the clinical observation and related immunity of Gushen Antang prescription combined with routine western medicine in treating recurrent spontaneous abortion of kidney and spleen. Methods: A retrospective analysis of randomly selected from February 2013 to December 2015 in our hospital admitted to recurrent spontaneous abortion (RSA) in patients with re-pregnancy in 60 cases, divided into two groups according to randomized group, A group of study group, using solid Kidney Antitu Infants with conventional Western medicine treatment program; B group as a reference group, the use of conventional Western medicine treatment. Results: There was no significant difference in the number of spontaneous abortion between groups A and B (P = 0.874). There was no significant difference in gestational age between the two groups of patients A and B (P = 0.516). The score of TCM symptom in group A and group B were (1.35 ± 4.98) and (11.86 ± 3.72) respectively at the time of first visit, and there was no significant difference in grade A and group B when they were newly diagnosed (P = 0.264). There was no significant difference in the serum levels of B-HCG and progesterone between groups A and B (P = 0.617). One patient in group A had failed in his litter and 29 patients were cured, with a total effective rate of 96.7%. B group of 10 cases of treatment ineffective, 20 cases were cured, the total effective rate was 66.7%. A, B two groups of patients after treatment of pregnancy outcome comparison, the difference was significant (P = 0.026). In group A, 8 cases were cured, 12 cases were markedly effective, 7 cases were effective and 3 cases were ineffective. The total effective rate was 90.0%. In group B, 4 cases were cured, 6 cases were markedly effective, 10 cases were effective and 10 cases were ineffective. The total effective rate was 66.7%. There was significant difference between the two groups in TCM symptom improvement after treatment (P = 0.042). A, B two groups of patients with the number of abortion and the outcome of the good comparison, after Fisher exact probability analysis, the difference was significant (P = 0.032). There was no significant difference between A and B groups in serum after treatment (P> 0.05). The difference of progesterone in group A and group B after 6 and 8 weeks of treatment was statistically significant (P <0.05). There was no significant difference in progesterone in group A and group B after 10 weeks of treatment (P> 0.05). Conclusion: Gushen Antong prescription combined with conventional western medicine has significant effect in treating recurrent spontaneous abortion of deficiency of both spleen and kidney, and is worth promoting.