论文部分内容阅读
目的:观察90例先兆流产患者保胎治疗后的妊娠结局,了解治疗前后血清肿瘤坏死因子—α(TNF-α)的变化,并探讨其与妊娠结局的相关性。方法:采用酶联免疫吸附法(ELISA)检测治疗前后患者血清中TNF-α的水平,并随访药物保胎治疗后继续妊娠者,了解其最终妊娠结局。结果:治疗前后患者TNF-α的变化有统计学意义(P<0.05);良好妊娠结局者与不良妊娠结局者治疗前TNF-α比较,没有统计学意义(P>0.05);良好妊娠结局者与不良妊娠结局者治疗后TNF-α比较,具有统计学意义(P<0.05)。结论:先兆流产患者经保胎治疗后母体外周血中TNF-α水平下降;TNF-α的异常表达与先兆流产的发病有关;先兆流产患者血清TNF-α水平的变化与妊娠结局有一定的相关性。
Objective: To observe the pregnancy outcome of 90 cases of threatened abortion after tocolytic treatment, and to understand the changes of serum tumor necrosis factor-α (TNF-α) before and after treatment and to explore its correlation with pregnancy outcome. Methods: The levels of TNF-α in serum of patients before and after treatment were detected by enzyme-linked immunosorbent assay (ELISA), and the follow-up of pregnancy-induced abortion was followed up to understand the final pregnancy outcome. Results: The changes of TNF-α in patients before and after treatment were statistically significant (P0.05) .There was no significant difference in TNF-α before and after treatment between good pregnancy outcome and adverse pregnancy outcome (P> 0.05). Good pregnancy outcome Compared with adverse pregnancy outcomes, TNF-α after treatment was statistically significant (P <0.05). Conclusion: The level of TNF-α in maternal peripheral blood decreased after threatened abortion. The abnormal expression of TNF-α was related to the incidence of threatened abortion. The change of serum TNF-α level in pregnant women with threatened abortion was related to the pregnancy outcome Sex.