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Using the Monte Carlo samples of about 800pb-1 and 500pb-1 generated at and around 3. 773 GeV with BOSS (BESⅢ Offline Software System) 6.0.2 and BOSS 6.1.0, we have studied the branching fractions for Do → K- l+ vland Do→π-l+vl(l = e, μ). According to the simulation results, the expected precision of these measurements for 20fb-1 ψ(3770) data which will be collected on BESⅢ are well estimated.