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为探讨中药黄芪对哮喘患儿免疫功能的影响，检测了在体外培养系统中加入黄芪水提剂后，１３例哮喘患儿及１０例健康儿童外周血单个核细胞（ＰＢＭＣ）产生ＩＦＮ－γ、ＩＬ－４及ＩｇＧ亚类水平的变化。结果显示黄芪明显促进ＰＨＡ诱导的ＰＢＭＣ产生ＩＦＮ－γ及ＰＷＭ诱导的ＰＢＭＣ产生ＩｇＧ１、ＩｇＧ２和ＩｇＧ３；但对ＰＢＭＣ产生ＩＬ－４及ＩｇＧ４无明显影响。结果提示黄芪可调节ＴＨ１及ＴＨ２细胞的部分功能，具有预防哮喘的感染诱因及调节患儿免疫功能的潜在意义。
To investigate the effect of Astragalus membranaceus on immune function in asthmatic children, the detection of IFN-γ production by peripheral blood mononuclear cells (PBMC) from 13 asthmatic children and 10 healthy children after adding Astragalus membranaceus water extract in vitro culture system, IL-4 and IgG subclasses level changes. The results showed that astragalus significantly promoted the production of IFN-γ by PBMCs induced by PHA and the production of IgG1, IgG2 and IgG3 by PBMCs induced by PWM, but had no significant effect on the production of IL-4 and IgG4 by PBMC. The results suggest that astragalus can regulate part of the function of TH1 and TH2 cells, with the incentive to prevent asthma and regulate the potential of immune function in children.