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目的探讨女性乙肝病毒(HBV)携带者行体外受精-胚胎移植(IVF-ET)助孕治疗后的妊娠结局。方法回顾性总结分析2010年3月至2012年12月在我中心因女性不孕进行IVF-ET助孕治疗的患者病历资料共422周期,以女方HBsAg阳性而男方HBsAg阴性为A组:HBV携带组共81个周期;双方均HBsAg阴性为B组:正常对照组共341个周期。比较两组的IVFET治疗结局。结果两组患者在年龄、不孕年限、Gn使用天数及总使用量、获卵数、移植胚胎数无差异的情况下,其受精率、卵裂率、D3优质胚胎率、胚胎种植率、临床妊娠率、早期流产率及总流产率亦无显著性差异(P>0.05)。结论女性HBV携带者行IVF-ET助孕治疗对妊娠结局没有影响。
Objective To investigate the pregnancy outcome of female carriers of hepatitis B virus (HBV) after IVF-ET assisted pregnancy. Methods Retrospectively analyzed and analyzed the clinical data of 422 cases of IVF-ET assisted pregnancy in female infertility from March 2010 to December 2012 in our center with HBsAg positive for the female and HBsAg negative for the male as Group A: HBV carriers A total of 81 cycles; both HBsAg negative for the B group: a normal control group a total of 341 cycles. IVFET treatment outcomes were compared between the two groups. Results The fertilization rate, cleavage rate, D3 high-quality embryo rate, embryo implantation rate, clinical stage, age, duration of infertility, days of Gn use and total usage, number of oocytes retrieved and number of embryos transferred did not differ between the two groups There was no significant difference in pregnancy rate, early abortion rate and total abortion rate (P> 0.05). Conclusion IVF-ET assisted pregnancy in women with HBV carriers has no effect on pregnancy outcome.