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[目的]探讨海藻酸钠微球(KMG)作为栓塞剂在子宫动脉栓塞术(UAE)治疗子宫肌瘤中的临床疗效和应用价值。[方法]选择106例子宫肌瘤患者,以单侧股动脉插管,并用5FRUC子宫动脉导管或加用3F同轴微导管超选择至双侧子宫动脉造影证实后,以KMG进行栓塞。[结果]以KMG行UAE治疗后,临床症状明显缓解,月经量减少53.4%±13.1%,用彩色多普勒超声诊断仪评价子宫和肌瘤大小及血流变化等,第12,18个月肌瘤体积分别缩小79.9%±8.7%、84.2%±8.9%,子宫体积分别缩小63.3%±5.6%、66.5%±7.4%。术后有不同程度的下腹痛、低热,持续1～2周不等,对症处理后消失。[结论]以KMG行UAE治疗子宫肌瘤可有效地缩小肌瘤及子宫的体积,并明显改善子宫肌瘤的临床症状。远期效果有待于观察。
[Objective] To investigate the clinical efficacy and value of sodium alginate microspheres (KMG) as an embolic agent in the treatment of uterine fibroids by uterine artery embolization (UAE). [Methods] 106 cases of uterine fibroids were selected, unilateral femoral artery catheterization and 5FRUC uterine artery catheter or plus 3F coaxial microcatheter ultrasound to bilateral uterine artery angiography confirmed KMG embolization. [Results] After treatment with KMG, the clinical symptoms were significantly relieved and the menstrual flow was reduced by 53.4% ± 13.1%. The size and blood flow of uterus and fibroids were evaluated by color Doppler sonography. At the 12th and 18th months The fibroids volume decreased by 79.9% ± 8.7%, 84.2% ± 8.9% and uterine volume by 63.3% ± 5.6% and 66.5% ± 7.4%, respectively. There are different degrees of lower abdominal pain, fever, lasted for 1 to 2 weeks, symptomatic treatment disappeared. [Conclusion] Treatment of uterine fibroids with KMG line UAE can effectively reduce the volume of fibroids and uterus, and significantly improve the clinical symptoms of uterine fibroids. The long-term effect needs to be observed.