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目的:探讨降钙素原(PCT)、C-反应蛋白(CRP)联合血清淀粉样蛋白A(SAA)检验在细菌性肺炎感染和病毒性肺炎感染中初期诊断的应用价值.方法:选择诊断为肺炎的105例患者,其中细菌性肺炎感染组60例、病毒性肺炎感染组45例,同时选取相同年龄段的健康查体者60例作为健康对照组.分别抽取2组患者及对照组空腹静脉血4 ml,应用免疫层析法进行PCT检测;应用胶体金法进行SAA检测,采用免疫增强透射比浊法行CRP检测,分别测定细菌性肺炎感染组、病毒性肺炎感染组及对照组的PCT、CRP和SAA浓度.结果: log(p/1-p) =-0.897 + 0.125×PCT+0.01×CRP,其中PCT的偏回归系数最大,表明PCT对细菌性肺炎结果诊断效能最大,log(p/1-p) = - 0.709 + 0.122×SAA+0.01×CRP,其中SAA的偏回归系数最大SAA对病毒性肺炎结果诊断效能最大.细菌性肺炎感染组PCT、CRP升高程度明显高于病毒性肺炎感染组及对照组(P＜0.05),病毒性肺炎感染组PCT、CRP升高程度水平与对照组比较差异无统计学意义(P＞0.05).结论:将PCT、CRP联合血清淀粉样蛋白A检验可协助临床对肺炎感染初期感染类型的鉴别诊断.“,”Objective:To investigate procalcitonin(PCT),C reactive protein(CRP)and serum amyloid A protein(SAA) to test the diagnostic value of early bacterial pneumonia and viral pneumonia infection. Method: A total of 105 patients with diagnosis of pneumonia were selected. There were 60 cases of bacterial pneumonia infection and 45 cases of viral pneumonia. Fasting blood 4ml was taken of the two groups of patients and the control group,PCT was detected by immunochromatographic assay,SAA was detected by colloidal gold method,and CRP was detected using immune turbidimetric method. PCT,CRP and SAA concentration were detected of viral pneumonia infection group,bacterial pneumonia group and control group,respectively. Result: Among the three groups,the differences of PCT,CRP and SAA level were statistically significant(P＜0.05);in viral pneumonia group and bacterial pneumonia group,PCT,CRP and SAA levels were higher than those of the control group;and the differences were statistically significant(P＜0.05),SAA of viral infection group and bacterial infection group was significantly higher than that of the control group(P＜0.05). PCT and CRP levels of the bacterial infection group were significantly higher than those of virus infection group and control group(P＜0.05);and in the virus infection group,PCT and CRP level had no statistical significance to the control group(P＞0.05). Conclusion:PCT and CRP combined with SAA detection could be used for the identification of respiratory tract infection and the diagnosis of bacterial pneumonia and viral pneumonia.