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慢性阻塞性肺疾病（COPD）易患肺内感染，经常反复使用抗生素。了解抗生素在肺组织中药浓度，对临床合理应用抗生素很有意义。检测痰中抗生素浓度，影响因素多，可靠性差。支气管肺泡灌洗液（BALF）药浓度可代替肺组织药浓度［’］。本文用反相高效液相色谱法检测COPD患者BALF
Chronic obstructive pulmonary disease (COPD) is predisposed to pulmonary infections and is frequently repeated antibiotics. Understanding of antibiotics in the lung tissue concentration of traditional Chinese medicine, rational use of antibiotics is meaningful. Detection of sputum antibiotic concentrations, many factors, poor reliability. Bronchoalveolar lavage fluid (BALF) drug concentration can replace the concentration of pulmonary drug [’]. In this paper, reversed phase high performance liquid chromatography in patients with COPD BALF