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目的：探讨兴奋性氨基酸对创伤性脑水肿的影响及作用机理。才法：在已建立的猫创伤性脑水肿模型基础上，伤后２０ｍｉｎ小脑延髓地内注入谷氨酸单钠溶液，伤后６ｈ测定两侧大脑半球脑含水量及阳离子含量变化。结果：与对照组比较，脑含水量及Ｎａ＋，Ｃａ２＋含量明显增加；Ｋ＋，Ｍｇ２＋含量则相应降低，这种变化具有剂量依赖性。结论：谷氨酸有加重创伤性脑水肿的作用，谷氨酸使Ｎａ＋和Ｃａ２＋内流增加可能是其加重脑水肿的主要病理生理机理。
Objective: To investigate the effect and mechanism of excitatory amino acids on traumatic brain edema. Talent: Based on the established model of traumatic cerebral edema in cats, monosodium glutamate solution was injected into the medulla oblongata of the injured cerebellum 20min after injury and the contents of water and cation in both hemispheres were measured 6h after injury. Results: Compared with the control group, brain water content and Na +, Ca2 + content increased significantly; K +, Mg2 + content decreased correspondingly, and the change was dose-dependent. CONCLUSION: Glutamate has the effect of aggravating traumatic cerebral edema. Increasing Na + and Ca2 + influx by glutamate may be the main pathophysiological mechanism of aggravating cerebral edema.