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目的比较希罗达方案和标准Mayo方案在结、直肠癌术后化疗中的疗效以及副反应。方法64例结、直肠癌术后患者随机分为两组化疗,A组接受希罗达方案,B组接受标准Mayo方案,观察两组在化疗中的疗效和副反应。结果A、B两组有效率分别为50.0%和43.8%,无显著性差异(p>0.05);A组副反应主要为腹泻(25%)、手足综合征(43.8%)、口炎(15.6%),B组副反应主要为骨髓抑制(37.5%)、恶心(25%)、呕吐(12.5%)。结论希罗达方案和标准Mayo方案均为结、直肠癌术后化疗有效方案;希罗达方案全身性副反应较轻,免住院治疗,较高耐受性及安全性,病人易于接受。
Objective To compare the efficacy and side effects of Xeloda and standard Mayo regimens in postoperative chemotherapy for colorectal cancer. Methods Sixty-four patients with colorectal cancer were divided into two groups randomly. Patients in group A received Xeloda regimen and group B received standard Mayo regimen. The curative effect and adverse reactions in both groups were observed. Results The effective rates in group A and group B were 50.0% and 43.8% respectively, with no significant difference (p> 0.05). The side effects in group A were mainly diarrhea (25%), hand-foot syndrome (43.8% %). The side effects in group B were mainly myelosuppression (37.5%), nausea (25%) and vomiting (12.5%). Conclusion The Xeloda and Mayo regimens are both effective regimens for the postoperative chemotherapy of colorectal cancer. The Xeloda regimen has mild systemic side effects and is exempt from hospitalization and has high tolerance and safety. The patients are easy to accept.