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目的对柳州市2005-2011年先天性甲状腺功能减低症筛查工作进行回顾性分析,了解其发病率及治疗情况。方法用时间分辨荧光法测定标准干血滤纸片全血中的促甲状腺素(thyroid stimulating hormone,TSH),确诊用化学发光免疫法检测可疑患者血清中的促甲状腺素(TSH)以及游离甲状腺素(FT4)。结果七年共筛查新生儿251617例,筛查率呈逐年上升趋势,至2011年达95%;共确诊甲低患儿156例,检出率为1/1613,高TSH血症912例,检出率为1/276。结论我市先天性甲状腺功能减低症的筛查率不断上升,使更多的先天性甲状腺功能减低症患儿得到早期诊断、早期治疗,避免了150多例患儿发育障碍,有效地控制了该出生缺陷给家庭和社会带来的危害,提高了出生人口素质。
Objective To retrospectively analyze the screening of congenital hypothyroidism in Liuzhou City from 2005 to 2011, and to understand the incidence and treatment of congenital hypothyroidism. Methods Thyroid stimulating hormone (TSH) in whole blood of standard dry blood filter paper was determined by time-resolved fluorescence spectroscopy. The levels of thyroxine (TSH) and free thyroxine (TSH) in serum of suspected patients were detected by chemiluminescence immunoassay FT4). Results A total of 251617 newborns were screened in seven years. The screening rate showed an upward trend year by year, up to 95% in 2011. A total of 156 children with hypothyroidism were diagnosed, with a detection rate of 1/1613 and 912 cases of high TSH. The detection rate is 1/276. Conclusion The screening rate of congenital hypothyroidism in our city is on the rise, enabling more patients with congenital hypothyroidism to get early diagnosis and early treatment, avoiding the developmental disorder of over 150 children and effectively controlling the Birth defects to the family and society hazards, improve the quality of the birth population.