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目的研究 p16基因产物在人肝外胆管癌中的表达及其意义.方法应用免疫组织化学技术检测51例肝外胆管癌组织中p16表达,并分析其意义.结果 51例肝外胆管腺癌 P16蛋白的阳性率为43.1%,其阳性率在肿瘤的病理分级及神经侵润等方面差异有显著性(P<0.05),中位生存期在 P16蛋白阳性的肿瘤中比阴性的长(23 mo vs 8mo,P<0.05),P16蛋白阳性比 P16阴性肿瘤手术切除率高(52.9% vs 23.5%,P<0.05).结论 p16基因可能在胆管肿瘤的发生、发展中起重要作用,与胆管癌分化不良、神经侵润、生存时间及能否切除有密切关系.
Objective To study the expression and significance of p16 gene product in human extrahepatic cholangiocarcinoma. Methods Immunohistochemistry was used to detect the expression of p16 in 51 cases of extrahepatic cholangiocarcinoma and its significance was analyzed. Results 51 cases of extrahepatic bile duct adenocarcinoma P16 The positive rate of protein was 43.1%, and the positive rate was significantly different in the pathological grade and nerve invasion of the tumor (P<0.05). The median survival time was longer in the tumor with positive P16 protein than in the negative (23 months). (vs 8 months, P<0.05). The positive rate of P16 protein was higher than that of P16 negative tumors (52.9% vs 23.5%, P<0.05). Conclusion p16 gene may play an important role in the occurrence and development of bile duct neoplasms, and cholangiocarcinoma Poor differentiation, neural invasion, survival time and ability to excise are closely related.