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血管内皮细胞参与血管内多种生理活动,内皮功能障碍将导致各种心血管疾病的发生。近几年来,研究发现新型气体信号分子硫化氢具有抗动脉粥样硬化等心血管疾病的效应:硫化氢促进内皮细胞增殖迁移诱导血管新生;抑制黏附分子分泌;通过打开平滑肌上ATP依赖性K+通道调节血管紧张度;抵抗氧化应激对内皮细胞的损伤等。随着其保护机制的不断发现与证实,硫化氢将有望逐渐应用于临床治疗,其对内皮的保护作用仍需要做进一步的研究。
Vascular endothelial cells involved in a variety of physiological activities within the blood vessels, endothelial dysfunction will lead to the occurrence of a variety of cardiovascular diseases. In recent years, the study found that a new type of gas signaling molecule hydrogen sulfide has anti-atherosclerotic cardiovascular disease effects: hydrogen sulfide promote endothelial cell proliferation and migration induced angiogenesis; inhibit adhesion molecule secretion; by opening the smooth muscle ATP-dependent K + channels Regulate vascular tone; resist oxidative stress on endothelial cell damage and so on. With the continuous discovery and confirmation of its protective mechanism, hydrogen sulfide is expected to be gradually applied to clinical treatment, and its protective effect on the endothelium still needs further study.