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作者们自1981年始对8例肿瘤引起的难以控制的恶病,采用脑室内注入小剂量吗啡治疗,效果良好,无毒性副作用。本文报道3例脑室内注射吗啡的方法及结果,并就其可能引起的并发症进行讨论。脑室内注入吗啡病人选择标准:(1)肿瘤引起的恶痛,对口服、皮下注射吗啡同时并用其它止痛剂有耐药者。(2)多发性转移瘤引起弥漫性疼痛。(3)根据肿瘤的恶性程度,病人只能短期生存者。(4)通常常规硬脊膜外腔注射吗啡无效者。(5)因局部有感染灶或硬脊膜外给药装置发生机械性故障,而必须停止硬
Since 1981, the authors have used eight small doses of morphine injected into the brain to control uncontrollable neoplasm caused by eight tumors. The results are good and there are no toxic side effects. This article reported the method and results of 3 cases of intracerebroventricular injection of morphine, and discussed the possible complications. Intraventricular injection of morphine patient selection criteria: (1) tumor-induced pain, oral, subcutaneous injection of morphine and other analgesics are resistant. (2) Multiple metastases cause diffuse pain. (3) According to the degree of malignancy of the tumor, the patient can only be a short-term survivor. (4) Ordinary spinal epidural injections of morphine are usually ineffective. (5) Mechanical failure must occur due to mechanical failure of localized infection or spinal epidural device