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作者比较了卡铂液和卡铂复合液对胃癌细胞株（ＮＫＭ－２５）细胞凋亡和ｐ５３蛋白表达的影响，研究表明随着卡铂液作用时间的延长，胃癌细胞凋亡数量和ｐ５３蛋白表达明显增加，免疫组织化学研究亦显示卡铂液作用后可以使胃癌细胞ｐ５３蛋白的表达增强。卡铂复合液对胃癌细胞凋亡数量和ｐ５３蛋白表达的影响与卡铂液的作用相比未见显著性差异（Ｐ＞０．０５）。研究提示：①卡铂液诱导胃癌细胞凋亡与ｐ５３蛋白的表达密切相关，可能为ｐ５３蛋白依赖性；②卡铂复合液保持了卡铂液所具有的对胃癌细胞凋亡的诱导作用。结合作者的前期研究，提示采用卡铂复合液腹腔内化疗，腹腔粘连和腹膜纤维化程度明显减轻，并发症少，是治疗胃肠道癌肿等的一种安全、有效的区域化疗方法。
The authors compared the effects of carboplatin and carboplatin on gastric cancer cell line (NKM-25) apoptosis and p53 protein expression, the study showed that with the carboplatin solution time, the number of gastric cancer cells apoptosis and p53 protein Expression was significantly increased, immunohistochemistry also showed that the role of carboplatin after gastric cancer cells can increase the expression of p53 protein. The effect of carboplatin on gastric cancer cell apoptosis and p53 protein expression was not significantly different from that of carboplatin (P> 0.05). The results suggest that: (1) Carboplatin induced apoptosis of gastric cancer cells is closely related to the expression of p53 protein, which may be dependent on p53 protein; (2) Carboplatin complex maintains the induction of apoptosis induced by carboplatin in gastric cancer cells. Combined with the author’s previous study, prompted the use of carboplatin liquid intraperitoneal chemotherapy, peritoneal adhesions and peritoneal fibrosis significantly reduced the degree of complications and less, is a safe and effective regional chemotherapy for gastrointestinal cancer and other chemotherapy.