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本文研究了111例正常妊娠和29例有各种胎儿畸形妊娠中期的羊水中锌和甲-胎蛋白(AFP)浓度,以及羊水中锌和甲-胎蛋白浓度间的关系。作者应用羊膜腔穿刺收集羊水标本,测定锌、甲-胎蛋白以及染色体分析。多数病例羊膜腔穿刺的指征是高龄(38岁以上),胎儿和母亲无任何临床异常。采集标本前,通过超声扫描确定每个病例的孕龄,检测锌,应用原子吸收分光光度计;检测AFP,应用双抗体免疫测定法,以及应用亲和色
In this paper, we examined the concentrations of zinc and alpha-fetoprotein (AFP) in amniotic fluid and the concentrations of zinc and alpha-fetoprotein in amniotic fluid in 111 normal and 29 pregnant women with various fetal malformations. The authors used amniocentesis to collect amniotic fluid specimens for determination of zinc, alpha-fetoprotein, and chromosomal analysis. Most cases of amniocentesis indications of elderly (over 38 years of age), fetus and mother without any clinical abnormalities. Prior to collection of the specimens, the gestational age was determined for each case by means of an ultrasound scan, the zinc content was measured, and the atomic absorption spectrophotometer was used; the AFP was detected using a double antibody immunoassay and the affinity color