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目的:观察盐酸川芎嗪注射液辅助治疗慢性阻塞性肺气肿临床疗效。方法:98例慢性阻塞性肺疾病患者随机分为研究组和对照组,各49例。研究组在常规治疗基础上采用盐酸川芎嗪注射液辅助治疗;对照组采用常规治疗。疗程30天。比较2组血液黏滞情况,包括高切黏度、低切黏度、血浆黏度和红细胞变形指数;第1秒用力呼气量(FEV1)、用力肺活量(FVC)指标;临床症状的改善情况。结果:总有效率研究组85.71%,对照组65.31%,2组比较,差异统计学意义(P<0.05)。治疗后研究组高切黏度、低切黏度、血浆黏度以及红细胞变形指数分别与对照组比较,差异有统计学意义(P<0.05)。治疗后研究组FEV1、FVC以及FEV1/FVC分别较对照组高,与对照组比较,差异有统计学意义(P<0.05)。治疗后研究组呼吸困难、咳痰效果及肺部啰音症状改善率与对照组比较,差异均有统计学意义(P<0.05)。结论:盐酸川芎嗪注射液辅助治疗慢性阻塞性肺气肿患者临床疗效更优,肺功能指标改善较好,能够有效改善患者的症状,提高患者生活质量。
Objective: To observe the curative effect of ligustrazine hydrochloride injection in the treatment of chronic obstructive pulmonary emphysema. Methods: A total of 98 patients with chronic obstructive pulmonary disease were randomly divided into study group and control group, 49 cases in each group. The study group was given adjuvant therapy with ligustrazine hydrochloride injection on the basis of routine treatment, while the control group was treated by routine therapy. Course of 30 days. Blood viscosity was compared between the two groups, including high shear viscosity, low shear viscosity, plasma viscosity and erythrocyte deformability index; FEV1 and FVC; and improvement of clinical symptoms. Results: The total effective rate was 85.71% in the study group and 65.31% in the control group, and the difference was statistically significant (P <0.05). The high shear viscosity, low shear viscosity, plasma viscosity and erythrocyte deformability index of the study group after treatment were significantly different from those of the control group (P <0.05). After treatment, FEV1, FVC and FEV1 / FVC in the study group were higher than those in the control group, respectively, and the difference was statistically significant (P <0.05). After treatment, dyspnea, sputum and pulmonary rales in the study group compared with the control group, the differences were statistically significant (P <0.05). Conclusion: Ligustrazine hydrochloride injection in patients with chronic obstructive pulmonary disease better clinical efficacy, better lung function indicators, can effectively improve the symptoms of patients and improve the quality of life of patients.