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目的探讨Survivin及Fas基因在膀胱移行细胞癌中的表达程度与肿瘤分级、分期及复发的关系。方法采用免疫组织化学SP法检测72例膀胱移行细胞癌、10例正常膀胱黏膜组织中Survivin及Fas基因的表达情况。分析Survivin和Fas基因表达与膀胱移行细胞癌的分级、分期及复发的关系。结果Survivin基因表达率随肿瘤级别升高而增高,在浸润性膀胱癌(T2～T4)及复发性膀胱癌中的表达显著增高。Fas基因表达率随肿瘤级别的升高而降低,在复发性膀胱癌中明显下降。结论Survivin基因与Fas基因的相互作用可能在膀胱癌的发展与侵袭中起重要作用。
Objective To investigate the relationship between the expression of Survivin and Fas in transitional cell carcinoma of the bladder and its relationship with tumor grade, stage and recurrence. Methods The expression of Survivin and Fas in 72 cases of bladder transitional cell carcinoma and 10 cases of normal bladder mucosa were detected by immunohistochemical SP method. To analyze the relationship between Survivin and Fas gene expression and the grade, stage and recurrence of bladder transitional cell carcinoma. Results The expression of Survivin increased with the increase of tumor grade, and was significantly increased in invasive bladder cancer (T2 ~ T4) and recurrent bladder cancer. The rate of Fas gene expression decreased with the increase of tumor grade and decreased significantly in recurrent bladder cancer. Conclusion The interaction between Survivin gene and Fas gene may play an important role in the development and invasion of bladder cancer.