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G蛋白偶联受体(GPCR)可以说是研究最普遍的一种受体,也是药物开发工作中的重要靶点,据统计超过30%的临床处方药是直接作用在GPCR上的,相关的研究已经获得了10次诺贝尔奖,GPCR的受重视程度可见一斑。GPCR主要通过G蛋白或者Arrestin信号转导行使功能,然而无论是G蛋白还是Arrestin,如何识别特异的受体产生的信号指令,并翻译成下游的功能的机制是不清楚的。中国科学院生物物理所的王江云课题组和山东大学医学院的孙金鹏课题组于2015年9月8号在权威期刊Nature communications上发表了
G protein-coupled receptors (GPCRs) are arguably the most commonly studied receptors and are important targets in drug development. More than 30% of clinical prescription drugs are directly acting on GPCRs, and related studies Has won 10 Nobel Prizes, GPCR’s attention is evident. GPCRs function mainly through G-protein or Arrestin signaling, however, whether G protein or Arrestin, mechanisms of how to recognize specific receptor-generated signaling and translate into downstream functions are unclear. Wang Jiangyun’s group of biophysics at the Chinese Academy of Sciences and Sun Jinpeng’s group at Shandong University School of Medicine published a report on Nature communications on September 8, 2015