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目的观察吉西他滨(Gem)和奥沙利铂(L-OPH)组成的GemOX方案联合地塞米松(DXM)治疗老年复发或难治性非霍奇金淋巴瘤(NHL)的临床疗效。方法复发或难治性NHL老年患者28例,应用GemOX联合地塞米松方案,即:Gem 1000mg/m2,静注,第一天;L-OHP85mg/m2,静注,第二天;地塞米松20mg,静注,第一天~第四天;14d为1个周期,完成4周期者做疗效评价。结果28例患者中,CR8例,PR10例,SD 4例,PD 6例,总有效率(CR+PR)为64.3%。结论GemOX联合地塞米松方案治疗老年复发及难治性NHL的近期疗效满意,毒副反应可耐受。
Objective To observe the clinical efficacy of GemOX combined with dexamethasone (DXM) consisting of gemcitabine (Gem) and oxaliplatin (L-OPH) in elderly relapsed or refractory non-Hodgkin lymphoma (NHL). Methods A total of 28 elderly patients with relapsed or refractory NHL were enrolled in this study. GemOX combined with dexamethasone (GemOX plus dexamethasone) was administered intravenously on the first day with L-OHP 85 mg / 20mg, intravenous injection, the first day to the fourth day; 14d for a period of 4 weeks to complete the efficacy evaluation. Results Of the 28 patients, 8 were CR, 10 were PR, 4 were SD, and 6 were PD. The total effective rate (CR + PR) was 64.3%. Conclusion GemOX combined with dexamethasone regimen in the treatment of elderly patients with relapsed and refractory NHL short-term efficacy of satisfactory, toxic side effects can be tolerated.