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目的探讨前列腺肾型透明细胞癌(RTCCC)的临床病理特点、免疫组化,提高对该肿瘤的认识。方法对1例发生于前列腺的肾型透明细胞癌进行病理观察,并结合文献讨论分析。结果前列腺肾型透明细胞癌的癌细胞胞质丰富,空亮,呈泡巢状、腺管状乃至实片状弥漫排列,须与转移性肾透明细胞癌及前列腺透明细胞癌相鉴别。免疫组化:AE1/AE3、低分子质量角蛋白(LMWCK)、EMA、PSA、P504S/AMACR和PSMA均(+),vimentin、CD10部分(+),高分子质量角蛋白(HMWCK)、CK7、PAX8和RCC(-)。结论前列腺肾型透明细胞癌是一种罕见的前列腺癌。正确诊断需要病理组织形态、免疫组化结合影像学检查及血清PSA水平。
Objective To investigate the clinicopathological characteristics, immunohistochemistry and the understanding of this tumor in clear cell renal cell carcinoma of the prostate (RTCCC). Methods One case of renal clear cell carcinoma in the prostate was observed by pathology and analyzed by literature. Results Prostate renal cell carcinoma of the clear cytoplasm of cancer cells rich in cytoplasm, empty, was bubble-shaped, glandular tubular shape and even diffuse arrangement, with metastatic renal clear cell carcinoma and clear cell differentiation of prostate clear. Immunohistochemistry: AE1 / AE3, low molecular weight keratin (LMWCK), EMA, PSA, P504S / AMACR and PSMA, vimentin, CD10 part, HMWCK, CK7, PAX8 and RCC (-). Conclusions Prostate kidney-type clear cell carcinoma is a rare form of prostate cancer. Correct diagnosis requires histopathology, immunohistochemistry combined with imaging and serum PSA levels.