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目的调查某院加强围手术期预防性应用抗菌药物管理的成效。方法于2006年3月(加强抗菌药物管理前)及2009年4月(加强抗菌药物管理后)2次对该院普通外科和骨科Ⅰ类切口手术围手术期抗菌药物应用合理性进行横断面调查。结果Ⅰ类切口手术围手术期抗菌药物使用率从2006年3月的91.16%下降至2009年4月的82.39%(x~2=5.24,P<0.05);用药合理率从35.07%升高至57.93%(x~2=14_61,P<0.05)。主要不合理方面为选药品种错误和术后用药时间过长,经加强管理后,均有所改善。结论该院围手术期预防性应用抗菌药物中存在一定的不合理因素,加强监管可以提高抗菌药物应用的合理性。
Objective To investigate the effectiveness of perioperative prophylactic antibiotics management in a hospital. Methods The cross-sectional survey of the rationality of perioperative antibacterials in general surgery and orthopedic class Ⅰ incision in the hospital was conducted twice in March 2006 (before strengthening the management of antibiotics) and in April 2009 (after strengthening the management of antibiotics) . Results The perioperative antibacterials utilization rate in Class Ⅰ incision decreased from 91.16% in March 2006 to 82.39% in April 2009 (x ~ 2 = 5.24, P <0.05). The reasonable rate of medication increased from 35.07% to 57.93% (x ~ 2 = 14_61, P <0.05). The main unreasonable aspects are the mistakes in drug selection and postoperative medication time, which have been improved after strengthened management. Conclusion There are some unreasonable factors in prophylactic use of antimicrobial agents during perioperative period in this hospital. Strengthening supervision can improve the rationality of antimicrobial drug application.