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目的探讨血清和腹腔积液中CA-50变化对消化系统恶性肿瘤的诊断价值。方法采用放射免疫法观察了54例正常人，176例消化系统常见恶性肿瘤和160例良性疾病病人血清CA-50含量。结果所测各种恶性肿瘤病人血清CA-50含量均显著高于正常人和相应脏器良性疾病病人；分别相比均有显著性差异（P＜0．001），良性疾病与正常人相比无显著性差异（P＞0．05）；且恶性肿瘤病人早期即有明显增高，晚期增高更为显著。结论血清和腹腔积液中CA－50的检测在消化系统良恶性疾病的诊断、鉴别诊断、病情估计，尤其是早期诊断和治疗后监测中均有一定实用价值。
Objective To investigate the diagnostic value of CA-50 changes in serum and peritoneal effusions for malignant tumors of the digestive system. Methods Radioimmunoassay was used to observe the serum CA-50 levels in 54 normal subjects, 176 cases of common malignant tumors of the digestive system and 160 cases of benign diseases. Results The levels of serum CA-50 in patients with various malignant tumors were significantly higher than those in normal people and patients with benign organ diseases; there were significant differences (P<0.001), and benign diseases were compared with normal people. There was no significant difference (P>0.05); patients with malignant tumors were significantly higher in the early stage and more significant in the late stage. Conclusion The detection of CA-50 in serum and peritoneal effusion is of practical value in the diagnosis, differential diagnosis, and disease assessment of the benign and malignant diseases of the digestive system, especially in early diagnosis and post-treatment monitoring.