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目的:回顾性分析托拉塞米联合甘油果糖治疗大面积脑梗死的疗效及安全性。方法:收集72例急性大面积脑梗死患者资料,根据治疗方案不同分为观察组和对照组。在常规治疗基础上,观察组予托拉塞米20 mg,ivd bid+甘油果糖250 ml,ivd bid。对照组予20%甘露醇125 ml,ivd q6h;2组均以治疗7 d评价疗效,托拉塞米、甘油果糖逐渐减量,疗程3周。治疗前和治疗14 d后检测电解质、肾功能、尿常规、超声心动图等观察指标,比较两组疗效。结果:观察组总有效率83.3%,明显优于对照组55.5%(P<0.01)。观察组电解质紊乱、肾功能不全等并发症比对照组显著减少(P<0.05)。结论:托拉塞米联合甘油果糖治疗大面积脑梗死效果好,可减少并发症的发生。
Objective: To retrospectively analyze the efficacy and safety of torsemide combined with glycerol fructose in the treatment of large-area cerebral infarction. Methods: The data of 72 patients with acute large area cerebral infarction were collected and divided into observation group and control group according to different treatment plans. On the basis of conventional treatment, the observation group received torsemide 20 mg, ivd bid + glycerol fructose 250 ml, ivd bid. Control group was given 20% mannitol 125 ml, ivd q6h; 2 groups were treated for 7 days to evaluate the efficacy of torasemide, glycerol fructose gradually reduced course of treatment for 3 weeks. Electrolytes, renal function, urine routine and echocardiography were observed before treatment and 14 days after treatment, and the curative effect was compared between the two groups. Results: The total effective rate in the observation group was 83.3%, which was significantly better than that in the control group (55.5%, P <0.01). Electrolyte disorders, renal insufficiency and other complications in the observation group were significantly reduced (P <0.05). Conclusion: Torasemide combined with glycerol fructose treatment of large-area cerebral infarction effect is good, can reduce the incidence of complications.