唐松草新碱多相脂质体静脉注射液与唐松草新碱盐酸盐静脉注射液的药物动力学研究

• 作 者: 何明焕 黄惠珍 马宛龙 马竹卿
• 机 构: 上海市长宁区中心医院抗癌药物研究室,上海市长宁区中心医院抗癌药物研究室,上海市长宁区中心医院抗癌药物研究室,上海市长宁区中心医院抗癌药物研究室 实习研究生 沈阳药学院
• 出 处: 中成药
• 发表日期: 1989年01期
• 关键词: 唐松草新碱 静脉注射液 药物动力学研究 盐酸盐 隔室模型 药时曲线 高效液相色谱 血样采集 移动相 基本处方

唐松草新碱多相脂质体静脉注射液与唐松草新碱盐酸盐静脉注射液的药物动力学研究结果表明,其分布与消除药时曲线均符合双隔室模型(r=0.99),但唐松草新碱多相脂质体的tβ~(1/2)为23.58 min,比唐松草新碱盐酸盐静脉注射液tβ~(1/2)11.23min为长;而消除前者则比后者慢。说明脂质体延缓了药物到组织的分布,减慢了药物从血循环中消除,药物在体内维持较高浓度和持续较长时间。

The results of pharmacokinetic studies on the intravenous injections of thalidomide multi-phase liposomal intravenous injection and safroleamicin hydrochloride hydrochloride showed that the distribution and elimination curves of the drug were in line with the two-compartment model (r=0.99). However, the t(beta)(1/2) of Thasangosoxine multiphase liposomes was 23.58 min, which was longer than that of tegezaine hydrochloride intravenous injection t(beta)(1/2) 11.23 min; but the elimination of the former was more than The latter is slow. It is suggested that the liposome delays the distribution of the drug to the tissue, slows the elimination of the drug from the blood circulation, and maintains the drug at a higher concentration in the body for a longer period of time.