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作者复习大量文献对应用阿司匹林防治急性心肌梗死(AMI)等有关问题进行简述。阿司匹林对AMI的一级预防Ridker等人报告,根据美国工程师健康研究方案(PPHS)对22071例男性健康医师(年龄40～84岁)进行为期5年的研究,其中半数服用阿司匹林(剂量325mg/d),半数服用安慰荆。结果AMI的发病率阿司匹林组比安慰剂组低44％(P<0.01)。但在发生AMI的病人中间在梗死范围、临床表现和血流动力学测定结果两组没有差异,说明服用阿司匹林能预防冠状动脉血栓形成,而不影响动脉粥样硬化的发生和经过。
The authors review a large literature review of aspirin in the prevention and treatment of acute myocardial infarction (AMI) and other related issues. Primary Prevention of AMI by Aspirin Ridker et al. Reported on a 5-year study of 22,071 male health physicians (aged 40-84 years) under the American Engineer’s Health Research Program (PPHS), of which half took aspirin at a dose of 325 mg / d ), Half take comfort Jing. Results The incidence of AMI was 44% lower in the aspirin group than in the placebo group (P <0.01). However, AMI patients in the infarction range, clinical manifestations and hemodynamic determination of the two groups no difference, indicating that taking aspirin can prevent coronary thrombosis, without affecting the occurrence and after atherosclerosis.