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目的 :探讨血清B型脑钠肽前体、AVP和内皮素在充血性心力衰竭(CHF)患者中的检测价值。方法 :选取我院明确诊断有CHF的118例不同病因、不同心功能分级患者以及同时期住院治疗的非CHF患者41例,测定所有受试对象入院时以及治疗前后的血清(血管紧张素)AVP、B型脑钠肽前体(NT-proNT-proBNP)、内皮素(ET-1)水平,比较发生心血管事件以及未发生心血管时间患者的AVP、NT-proBNP、内皮素(ET-1)水平。结果 :心衰患者的NT-proBNP、AVP、ET-1水平均明显高于正常对照组,CHF患者的血浆NT-proBNP、AVP、ET-1水平随着心功能不全的加重而明显升高,治疗后均较治疗前明显改善,心脏发生事件组的NT-proBNP、AVP、ET-1水平均明显高于无事件组,组间比较有统计学差异。结论 :血清B型脑钠肽前体、AVP和内皮素在CHF患者中的检测对于判断CHF患者的病情严重度以及预后有着积极的意义,尤其在治疗后对其浓度进行监测对于CHF的风险评估具有重要的意义。
Objective: To investigate the value of serum B-type natriuretic peptide precursor, AVP and endothelin in patients with congestive heart failure (CHF). Methods: A total of 118 patients with different etiologies, with different cardiac function scores and 41 hospitalized non-CHF patients with definite diagnosis of CHF in our hospital were enrolled in this study. Serum (angiotensin) (AVP) levels at admission and before and after treatment were measured in all subjects NT-proBNP, and ET-1 levels in patients with cardiovascular events and those without cardiovascular events were compared. The levels of ET-1, NT-proBNP and endothelin )Level. Results: The levels of NT-proBNP, AVP and ET-1 in patients with heart failure were significantly higher than those in the normal control group. The levels of plasma NT-proBNP, AVP and ET-1 in patients with CHF were significantly increased with the worsening of cardiac insufficiency, The levels of NT-proBNP, AVP and ET-1 in the cardiac events group were significantly higher than those in the non-event group after treatment, and there were significant differences between the two groups. Conclusion: The detection of serum B-type natriuretic peptide precursor, AVP and endothelin in CHF patients is of great significance in judging the severity and prognosis of patients with CHF, especially for monitoring the risk of CHF after treatment It is of great significance.